Stability of flowing open fluidic channels

Single Cell Microinjection Using Compliant Fluidic Channels

We present a fully scalable cell injection system in a lab on a chip format that allows for on-chip cell pre-processing, injection and post-processing. Injection is performed by an integrated microneedle which is actuated by the compliant deformation of the PDMS (polydimethylsiloxane) fluidic channel by a single axis actuator. The needle actuation is 90.9% of the applied displacement. The cells...

Electrokinetic molecular separation in nanoscale fluidic channels.

This report presents a study of electrokinetic transport in a series of integrated macro- to nano-fluidic chips that allow for controlled injection of molecular mixtures into high-density arrays of nanochannels. The high-aspect-ratio nanochannels were fabricated on a Si wafer using interferometric lithography and standard semiconductor industry processes, and are capped with a transparent Pyrex...

Micro-Fluidic Channels with Integrated Ultrasonic Transducers

This paper describes the work done in an attempt to integrate ultrasonic sensors in micro-fluidic channels. We have developed a system with fluidic channels having embedded zinc oxide transducers. A zinc oxide film is deposited on a glass substrate and is sandwiched between two electrodes. The transducers made are found to resonate at 400 MHz in thickness mode. The channels are made both from P...

Critical stability number in rock lined channels

Electrical Detection of DNA and Integration with Nano-fluidic Channels

The elongation of genomic length DNA in confining nanochannels is not only a fascinating exercise in polymer dynamics, but also is of great interest in biotechnology because the elongation of the confined molecule is directly proportional to the actual length of the molecule in basepairs. Precision length measurements of genomic length DNA molecules are useful because most of the mutations are ...